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A simple synthetic procedure allows the conversion of a wide variety of carboxylic acid to hydroxamates. Synthesis of Weinreb Amides Using Triazime Intermediates De Luca et al 37 reported the successful large scale synthesis of weinreb amide through a convenient and simple one-flask method via 2-chloro-4,6-dimethoxy-1,3,5-triazine intermediate 20. The reaction of carboxylic acid 1eq and 2-chloro-4,6-dimethoxy-1,3,5-triazine 1.2 eq in the presence of N-methyl morpholine 3 eq., THF at room temperature for 1-3 h gave the 4,6-dimethoxy-1,3,5-triazine intermediate 20, compound 20 upon treatment with substituted hydroxylamine 1 eq at room temperature for 8 h gave the target product 21. This silencing can become permanent if the unprotected lysines are then methylated. HDAC performs the reverse process of histone acetyl co A to the lysines on the histone, inducing a state known as hyper acetylation. 29 The wide biological application of hydroxamates necessitates the review of its synthesis and biological applications. General Synthesis of Weinreb Amides Hydroxamic acids are prepared usually from esters or acid chlorides or carboxylic acids.2.1.

Protection of the commercially available hydro ester 22 with tertiary-butyldimethylsilyl chloride TBDMS-Cl gave silyl ester 23. Ugwuja3 1Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka, Nigeria 2National Centre for Energy Research and Development, University of Nigeria, Nsukka, Nigeria 3Department of Chemical Sciences, Federal University, Wukari, Nigeria Correspondence to: David I. Introduction Hydroxamates are class of organic compounds bearing the functional group RICON OH RII as organic residues and CO as a carbonyl group. The syntheses of various classes of hydroxamates and their mode of biological applications have been reviewed. 4 Much of their activities are due to their chelating properties with metal ions, especially with transition metals, hence constituting a very important class of chelating agents with versatile biological activities. The ester 23 on reduction with Li BH4 gave the alcohol. Oxidation of alcohol 24 under Swern condition 47 gave aldehyde 25 which was treated with an aryl Grignard reagent to produce alcohol 26.

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